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期刊名称: Perspectives on Psychological Science
Volume:1    Issue:1        Page:5-27
ISSN:1745-6916

Measured Gene-Environment Interactions in Psychopathology: Concepts, Research Strategies, and Implications for Research, Intervention, and Public Understanding of Genetics期刊论文

作者: Terrie E. Moffitt Avshalom Caspi Michael Rutter
DOI:10.1111/j.1745-6916.2006.00002.x

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页码: 5-27
被引频次: 215
出版者: Blackwell Publishing,SAGE Publications,SAGE PUBLICATIONS LTD
期刊名称: Perspectives on Psychological Science
ISSN: 1745-6916
卷期: Volume:1    Issue:1
语言: English
摘要: There is much curiosity about interactions between genes and environmental risk factors for psychopathology, but this interest is accompanied by uncertainty. This article aims to address this uncertainty. First, we explain what is and is not meant by gene-environment interaction. Second, we discuss reasons why such interactions were thought to be rare in psychopathology, and argue instead that they ought to be common. Third, we summarize emerging evidence about gene-environment interactions in mental disorders. Fourth, we argue that research on gene-environment interactions should be hypothesis driven, and we put forward strategies to guide future studies. Fifth, we describe potential benefits of studying measured gene-environment interactions for basic neuroscience, gene hunting, intervention, and public understanding of genetics. We suggest that information about nurture might be harnessed to make new discoveries about the nature of psychopathology.
相关主题: Pathogens, Genetic variation, Medical genetics, Genetic research, Environmental disorders, Environmental risk, Mental illness, Behavioral genetics, Human genetics, Genotypes, PSYCHOLOGY, MULTIDISCIPLINARY,

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