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期刊名称: Environmental Toxicology
Volume:30    Issue:2        Page:149-160
ISSN:1520-4081

Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic effect of silver nanoparticles in human lung epithelial cells期刊论文

作者: Suliman Y Al Omar Ali Daoud Alarifi Saud Harrath Abdul Halim Mansour Lamjed
DOI:10.1002/tox.21880

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页码: 149-160
被引频次: 45
出版者: WILEY,Wiley Subscription Services, Inc
期刊名称: Environmental Toxicology
ISSN: 1520-4081
卷期: Volume:30    Issue:2
语言: English
摘要: ABSTRACT Silver nanoparticles are increasingly used in various products, due to their antibacterial properties. Despite its wide spread use, only little information on possible adverse health effects exists. Therefore, the aim of this study was to assess the toxic potential of silver nanoparticles (<100 nm) in human lung epithelial (A549) cells and the underlying mechanism of its cellular toxicity. Silver nanoparticles induced dose and time‐dependent cytotoxicity in A549 cells demonstrated by MTT and LDH assays. Silver nanoparticles were also found to induce oxidative stress in dose and time‐dependent manner indicated by depletion of GSH and induction of ROS, LPO, SOD, and catalase. Further, the activities of caspases and the level of proinflammatory cytokines, namely interleukin‐1β (IL‐1β) and interleukin‐6 (IL‐6) were significantly higher in treated cells. DNA damage, as measured by single cell gel electrophoresis, was also dose and time‐dependent signicants in A549 cells. This study investigating the effects of silver nanoparticles in human lung epithelial cells has provided valuable insights into the mechanism of potential toxicity induced by silver nanoparticles and warrants more careful assessment of silver nanoparticles before their industrial applications. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 149–160, 2015.
相关主题: proinflammatory cytokines, silver nanoparticles, cyto‐genotoxicity, oxidative stress, human lung epithelial cells, Human lung epithelial cells, Oxidative stress, Proinflammatory cytokines, Cyto-genotoxicity, Silver nanoparticles, ASSAY, PARTICLES, MECHANISM, DNA-DAMAGE, QUANTITATION, WATER RESOURCES, TOXICITY, ENVIRONMENTAL SCIENCES, IN-VITRO, NANOSILVER, CERIUM OXIDE NANOPARTICLES, ULTRAFINE, cyto-genotoxicity, TOXICOLOGY, Biomarkers - metabolism, Inflammation - chemically induced, L-Lactate Dehydrogenase - metabolism, Cell Line, Cell Survival - drug effects, Inflammation - pathology, Mutagens - toxicity, Reactive Oxygen Species - metabolism, Respiratory Mucosa - cytology, Respiratory Mucosa - drug effects, Apoptosis - drug effects, Epithelial Cells - drug effects, Humans, Metal Nanoparticles - toxicity, Mutagenicity Tests, Lipid Peroxidation - drug effects, Silver - toxicity, Oxidative Stress - drug effects, Nanoparticles, Analysis,

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