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期刊名称: Clinical Oral Investigations
Volume:20    Issue:9        Page:2353-2360
ISSN:1432-6981

Comparative release of growth factors from PRP, PRF, and advanced-PRF期刊论文

作者: Kobayashi Eizaburo Flückiger Laura Fujioka-Kobayashi Masako Sawada Kosaku Sculean Anton
DOI:10.1007/s00784-016-1719-1

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页码: 2353-2360
被引频次: 50
出版者: Springer Berlin Heidelberg,SPRINGER HEIDELBERG,Springer,Springer Science & Business Media
期刊名称: Clinical Oral Investigations
ISSN: 1432-6981
卷期: Volume:20    Issue:9
语言: English
摘要: The use of platelet concentrates has gained increasing awareness in recent years for regenerative procedures in modern dentistry. The aim of the present study was to compare growth factor release over time from platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and a modernized protocol for PRF, advanced-PRF (A-PRF).Eighteen blood samples were collected from six donors (3 samples each for PRP, PRF, and A-PRF). Following preparation, samples were incubated in a plate shaker and assessed for growth factor release at 15 min, 60 min, 8 h, 1 day, 3 days, and 10 days. Thereafter, growth factor release of PDGF-AA, PDGF-AB, PDGF-BB, TGFB1, VEGF, EGF, and IGF was quantified using ELISA.The highest reported growth factor released from platelet concentrates was PDGF-AA followed by PDGF-BB, TGFB1, VEGF, and PDGF-AB. In general, following 15–60 min incubation, PRP released significantly higher growth factors when compared to PRF and A-PRF. At later time points up to 10 days, it was routinely found that A-PRF released the highest total growth factors. Furthermore, A-PRF released significantly higher total protein accumulated over a 10-day period when compared to PRP or PRF.The results from the present study indicate that the various platelet concentrates have quite different release kinetics. The advantage of PRP is the release of significantly higher proteins at earlier time points whereas PRF displayed a continual and steady release of growth factors over a 10-day period. Furthermore, in general, it was observed that the new formulation of PRF (A-PRF) released significantly higher total quantities of growth factors when compared to traditional PRF.Based on these findings, PRP can be recommended for fast delivery of growth factors whereas A-PRF is better-suited for long-term release.
相关主题: Growth factor release, Choukroun’s PRF, Platelet-rich fibrin, Dentistry, Platelet concentrates, Platelet-rich plasma, Choukroun's PRF, CELLS IN-VITRO, GUIDED TISSUE REGENERATION, MAXILLOFACIAL SURGERY, FIBRIN PRF, CHRONIC PERIODONTITIS, CURRENT KNOWLEDGE, CONTROLLED CLINICAL-TRIAL, PLATELET-RICH PLASMA, 3-WALL INTRABONY DEFECTS, DENTISTRY, ORAL SURGERY & MEDICINE, PERSPECTIVES, Platelet rich plasma, Intercellular Signaling Peptides and Proteins - metabolism, Enzyme-Linked Immunosorbent Assay, Blood Platelets - metabolism, Humans, Middle Aged, Adult, Fibrin - metabolism, Platelet-Rich Plasma - metabolism, Intercellular Signaling Peptides and Proteins - blood, Comparative analysis, Fibrin, Growth factors,

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