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期刊名称: Current Opinion in Chemical Biology
Volume:16    Issue:5-6        Page:595-601
ISSN:1367-5931

Fluorescent probes for sensing and imaging biological hydrogen sulfide期刊论文

作者: Lin Vivian S Chang Christopher J
DOI:10.1016/j.cbpa.2012.07.014

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页码: 595-601
被引频次: 184
出版者: Elsevier Ltd,ELSEVIER SCI LTD,Elsevier B.V
期刊名称: Current Opinion in Chemical Biology
ISSN: 1367-5931
卷期: Volume:16    Issue:5-6
语言: English
摘要: ► Hydrogen sulfide (H S) can mediate physiology and disease pathology in mammalian systems. ► The development of molecular probes for H S detection allows H S to be studied in intact cells, tissues, or whole organisms. ► Current probes employ a variety of reaction-based strategies to achieve selectivity for H S over other biological thiols. Hydrogen sulfide (H S) has long been recognized as a toxic molecule in biological systems. However, emerging studies now link controlled fluxes of this reactive sulfur species to cellular regulation and signaling events akin to other small molecule messengers, such as nitric oxide, hydrogen peroxide, and carbon monoxide. Progress in the development of fluorescent small-molecule indicators with high selectivity for hydrogen sulfide offers a promising approach for studying its production, trafficking, and downstream physiological and/or pathological effects.
相关主题: BIOPHYSICS, BIOCHEMISTRY & MOLECULAR BIOLOGY, IN-VIVO, NITRIC-OXIDE, INSULIN-RELEASE, SYSTEMS, SULFUR, TISSUES, H2S BIOGENESIS, BRAIN, LIVING CELLS, PEROXIDE, Hydrogen Sulfide - analysis, Molecular Imaging - methods, Animals, Humans, Optical Imaging - methods, Fluorescent Dyes - analysis, Hydrogen sulfide,

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