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期刊名称: Current Opinion in Chemical Biology
Volume:14    Issue:3        Page:347-361
ISSN:1367-5931

Privileged scaffolds for library design and drug discovery期刊论文

作者: Welsch Matthew E Snyder Scott A Stockwell Brent R
DOI:10.1016/j.cbpa.2010.02.018

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页码: 347-361
被引频次: 757
出版者: Elsevier Ltd,ELSEVIER SCI LTD
期刊名称: Current Opinion in Chemical Biology
ISSN: 1367-5931
卷期: Volume:14    Issue:3
语言: English
摘要: This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.
相关主题: TARGET, POTENT, DIVERSITY-ORIENTED SYNTHESIS, BIOPHYSICS, PURINE, NATURAL-PRODUCTS, BIOCHEMISTRY & MOLECULAR BIOLOGY, CHEMISTRY, LEADS, MOLECULES, Small Molecule Libraries - chemistry, Models, Chemical, Humans, Receptors, Cytoplasmic and Nuclear - chemistry, Pharmaceutical Preparations - chemistry, Protein Binding, Small Molecule Libraries - chemical synthesis, Drug Discovery - methods, Drug Delivery Systems - methods, Receptors, Cytoplasmic and Nuclear - metabolism,

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