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Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice期刊论文

作者: Kong-Yan Wu Guo-Long Zuo Xiao-Feng Li Qing Ye Yong-Qiang Deng Xing-Yao Huang Wu-Chun Cao Cheng-Feng Qin Zhen-Ge Luo
DOI:10.1038/cr.2016.58

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页码: 645-654
被引频次: 153
出版者: NATURE PUBLISHING GROUP,Nature Publishing Group
ISSN: 1001-0602
卷期: Volume:26    Issue:6
语言: English
摘要: The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal (i.p.) injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial gila cells (RGs) of dorsal ventricular zone of the fetuses, the primary neural progenitors responsi- ble for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports l;he conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies.
相关主题: 垂直传播, 病毒, 皮质, 放射状, 小鼠, 胶质细胞, 大脑发育, 后代, vertical transmission, Zika virus, cortical development, radial glial cells, AMERICA, INFECTION, BRAIN, BRAZIL, CELL BIOLOGY, Cell Cycle - genetics, Cell Proliferation, Microcephaly - genetics, Zika Virus Infection - pathology, Mice, Inbred C57BL, Zika Virus - physiology, Cerebral Cortex - pathology, Gene Expression Regulation, Fetus - pathology, Cerebral Cortex - virology, Microcephaly - virology, Neural Stem Cells - pathology, Zika Virus Infection - transmission, Zika Virus Infection - virology, Animals, Cerebral Cortex - embryology, Microcephaly - pathology, Fetus - virology, Ependymoglial Cells - pathology, Cerebral Cortex - abnormalities, Ependymoglial Cells - virology, Original,

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