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Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis期刊论文

作者: Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang
DOI:10.1038/cr.2015.82

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页码: 981-984
被引频次: 465
出版者: INST BIOCHEMISTRY & CELL BIOLOGY,Nature Publishing Group
ISSN: 1001-0602
卷期: Volume:25    Issue:8
语言: English
摘要: Circular RNAs (circRNAs) are recently identified as a naturally occurring family of widespread and diverse endogenous noncoding RNAs that may regulate gene expression in mammals . They are unusually sta- ble RNA molecules with cell type- or developmental stage-specific expression patterns . Exosomes are small membrane vesicles of endocytic origin secreted by most cell types. They contain a specific cargo of protein, mRNA and microRNA species, which can modulate recipient cell behaviors and may be used as biomarkers for diagnosis of human diseases .
相关主题: 诊断, 癌症, 非编码RNA, 发育阶段特异性, 生物标志物, 稳定, 循环, 细胞类型, CELL BIOLOGY, Exosomes - metabolism, Animals, Early Detection of Cancer - methods, RNA - analysis, Humans, Neoplasms, Experimental - diagnosis, Neoplasms, Experimental - genetics, Biomarkers, Tumor, RNA - genetics, Letter to the Editor,

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