National Science Library, Chinese Academy of Sciences
  登录 机构网站 ENGLISH
您当前的位置是:首页->详细浏览

期刊名称: Trends in Biochemical Sciences
Volume:39    Issue:4        Page:170-182
ISSN:0968-0004

Enhancer RNAs and regulated transcriptional programs期刊论文

作者: Lam Michael T.Y Li Wenbo Rosenfeld Michael G Glass Christopher K
DOI:10.1016/j.tibs.2014.02.007

服务链接:
页码: 170-182
被引频次: 210
出版者: Elsevier Ltd,ELSEVIER SCIENCE LONDON,Elsevier Science Publishers
期刊名称: Trends in Biochemical Sciences
ISSN: 0968-0004
卷期: Volume:39    Issue:4
语言: English
摘要: A large portion of the human genome is transcribed into RNAs without known protein-coding functions, far outnumbering coding transcription units. Extensive studies of long noncoding RNAs (IncRNAs) have clearly demonstrated that they can play critical roles in regulating gene expression, development, and diseases, acting both as transcriptional activators and repressors. More recently, enhancers have been found to be broadly transcribed, resulting in the production of enhancer-derived RNAs, or eRNAs. Here, we review emerging evidence suggesting that at least some eRNAs contribute to enhancer function. We discuss these findings with respect to potential mechanisms of action of eRNAs and other ncRNAs in regulated gene expression.
相关主题: enhancer, noncoding RNA, transcription, eRNA, BIOCHEMISTRY & MOLECULAR BIOLOGY, INTERGENIC TRANSCRIPTION, BETA-GLOBIN LOCUS, ESTROGEN-RECEPTOR BINDING, BREAST-CANCER, LOCUS-CONTROL REGION, HS2 ENHANCER, LONG NONCODING RNA, GENE-EXPRESSION, POLYMERASE-II, CHROMATIN INTERACTIONS, Animals, Disease - genetics, Enhancer Elements, Genetic, RNA, Untranslated - metabolism, Humans, Gene Expression Regulation, Transcription, Genetic, RNA, Untranslated - genetics, Genetic aspects, Genetic transcription,

相关文献推荐:

问图书管理员更多图书管理员

学科咨询馆员
学科馆员

电话:
邮件:
问图书馆员

图标说明

在线获取原文 原文传递 详细信息 图书在架状态 图书馆际互借 问图书馆员

常见问题

图书馆开放时间 图书馆位置 借阅要求 您在使用中发现的任何错误,都可以向我们 【报告错误】,非常感谢!

作者信息:×