National Science Library, Chinese Academy of Sciences
  登录 机构网站 ENGLISH
您当前的位置是:首页->详细浏览

期刊名称: HUMAN GENETICS
Volume:126    Issue:1        Page:51-90
ISSN:0340-6717

Candidate gene studies of ADHD: a meta-analytic review期刊论文

作者: Gizer IR Ficks C Waldman ID
DOI:10.1007/s00439-009-0694-x

服务链接:
页码: 51-90
被引频次: 569
出版者: SPRINGER,Springer Science & Business Media
期刊名称: HUMAN GENETICS
ISSN: 0340-6717
卷期: Volume:126    Issue:1
语言: English
摘要: Quantitative genetic studies (i.e., twin and adoption studies) suggest that genetic influences contribute substantially to the development of attention deficit hyperactivity disorder (ADHD). Over the past 15 years, considerable efforts have been made to identify genes involved in the etiology of this disorder resulting in a large and often conflicting literature of candidate gene associations for ADHD. The Wrst aim of the present study was to conduct a comprehensive meta-analytic review of this literature to determine which candidate genes show consistent evidence of association with childhood ADHD across studies. The second aim was to test for heterogeneity across studies in the effect sizes for each candidate gene as its presence might suggest moderating variables that could explain inconsistent results. Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25. Further, significant heterogeneity was observed for the associations between ADHD and DAT1, DRD4, DRD5, DBH, ADRA2A, 5HTT, TPH2, MAOA, and SNAP25, suggesting that future studies should explore potential moderators of these associations (e.g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD.
相关主题: ATTENTION-DEFICIT-HYPERACTIVITY, CATECHOL-O-METHYLTRANSFERASE, MONOAMINE-OXIDASE-A, GENETICS & HEREDITY, DEFICIT/HYPERACTIVITY DISORDER ADHD, DOPAMINE TRANSPORTER GENE, ALPHA-2A ADRENERGIC-RECEPTOR, ACETYLCHOLINE-RECEPTOR-ALPHA-4 SUBUNIT GENE, FAMILY-BASED ASSOCIATION, TANDEM DUPLICATION POLYMORPHISM, ACTIVITY-DEPENDENT SECRETION, Dopamine D5 receptors, Reviews, Etiology, Attention deficit hyperactivity disorder, SNAP-25 protein, Children, Twins, Dopamine D4 receptors, Risk factors, Adoption, Humans, Attention Deficit Disorder with Hyperactivity, SLC6A3 protein, human, SNAP25 protein, human, Receptors, Adrenergic, alpha-2, Tryptophan Hydroxylase, Dopamine beta-Hydroxylase, Genetic Markers, Receptor, Serotonin, 5-HT2A, Case-Control Studies, Polymorphism, Genetic, Receptor, Serotonin, 5-HT1B, ADRA2A protein, human, TPH2 protein, human, Receptors, Dopamine D5, Receptors, Dopamine D4, Alleles, Synaptosomal-Associated Protein 25, Monoamine Oxidase, Child, Dopamine Plasma Membrane Transport Proteins, Receptors, Adrenergic, alpha-2 - genetics, Synaptosomal-Associated Protein 25 - genetics, Receptor, Serotonin, 5-HT2A - genetics, Monoamine Oxidase - genetics, Dopamine Plasma Membrane Transport Proteins - genetics, Receptors, Dopamine D4 - genetics, Tryptophan Hydroxylase - genetics, Attention Deficit Disorder with Hyperactivity - genetics, Dopamine beta-Hydroxylase - genetics, Receptor, Serotonin, 5-HT1B - genetics, Receptors, Dopamine D5 - genetics,

相关文献推荐:

问图书管理员更多图书管理员

学科咨询馆员
学科馆员

电话:
邮件:
问图书馆员

图标说明

在线获取原文 原文传递 详细信息 图书在架状态 图书馆际互借 问图书馆员

常见问题

图书馆开放时间 图书馆位置 借阅要求 您在使用中发现的任何错误,都可以向我们 【报告错误】,非常感谢!

作者信息:×