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Volume:126    Issue:1        Page:51-90

Candidate gene studies of ADHD: a meta-analytic review期刊论文

作者: Gizer IR Ficks C Waldman ID

页码: 51-90
被引频次: 569
出版者: SPRINGER,Springer Science & Business Media
ISSN: 0340-6717
卷期: Volume:126    Issue:1
语言: English
摘要: Quantitative genetic studies (i.e., twin and adoption studies) suggest that genetic influences contribute substantially to the development of attention deficit hyperactivity disorder (ADHD). Over the past 15 years, considerable efforts have been made to identify genes involved in the etiology of this disorder resulting in a large and often conflicting literature of candidate gene associations for ADHD. The Wrst aim of the present study was to conduct a comprehensive meta-analytic review of this literature to determine which candidate genes show consistent evidence of association with childhood ADHD across studies. The second aim was to test for heterogeneity across studies in the effect sizes for each candidate gene as its presence might suggest moderating variables that could explain inconsistent results. Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25. Further, significant heterogeneity was observed for the associations between ADHD and DAT1, DRD4, DRD5, DBH, ADRA2A, 5HTT, TPH2, MAOA, and SNAP25, suggesting that future studies should explore potential moderators of these associations (e.g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD.
相关主题: ATTENTION-DEFICIT-HYPERACTIVITY, CATECHOL-O-METHYLTRANSFERASE, MONOAMINE-OXIDASE-A, GENETICS & HEREDITY, DEFICIT/HYPERACTIVITY DISORDER ADHD, DOPAMINE TRANSPORTER GENE, ALPHA-2A ADRENERGIC-RECEPTOR, ACETYLCHOLINE-RECEPTOR-ALPHA-4 SUBUNIT GENE, FAMILY-BASED ASSOCIATION, TANDEM DUPLICATION POLYMORPHISM, ACTIVITY-DEPENDENT SECRETION, Dopamine D5 receptors, Reviews, Etiology, Attention deficit hyperactivity disorder, SNAP-25 protein, Children, Twins, Dopamine D4 receptors, Risk factors, Adoption, Humans, Attention Deficit Disorder with Hyperactivity, SLC6A3 protein, human, SNAP25 protein, human, Receptors, Adrenergic, alpha-2, Tryptophan Hydroxylase, Dopamine beta-Hydroxylase, Genetic Markers, Receptor, Serotonin, 5-HT2A, Case-Control Studies, Polymorphism, Genetic, Receptor, Serotonin, 5-HT1B, ADRA2A protein, human, TPH2 protein, human, Receptors, Dopamine D5, Receptors, Dopamine D4, Alleles, Synaptosomal-Associated Protein 25, Monoamine Oxidase, Child, Dopamine Plasma Membrane Transport Proteins, Receptors, Adrenergic, alpha-2 - genetics, Synaptosomal-Associated Protein 25 - genetics, Receptor, Serotonin, 5-HT2A - genetics, Monoamine Oxidase - genetics, Dopamine Plasma Membrane Transport Proteins - genetics, Receptors, Dopamine D4 - genetics, Tryptophan Hydroxylase - genetics, Attention Deficit Disorder with Hyperactivity - genetics, Dopamine beta-Hydroxylase - genetics, Receptor, Serotonin, 5-HT1B - genetics, Receptors, Dopamine D5 - genetics,






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