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期刊名称: Blood Reviews
Volume:25    Issue:4        Page:155-167
ISSN:0268-960X

Platelets at work in primary hemostasis期刊论文

作者: Broos Katleen|Feys Hendrik B.|De Meyer Simon F.|Vanhoorelbeke Karen|Deckmyn Hans
DOI:10.1016/j.blre.2011.03.002

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页码: 155-167
被引频次: 149
出版者: Elsevier Ltd,CHURCHILL LIVINGSTONE,Elsevier B.V
期刊名称: Blood Reviews
ISSN: 0268-960X
卷期: Volume:25    Issue:4
语言: English
摘要: Abstract When platelet numbers are low or when their function is disabled, the risk of bleeding is high, which on the one hand indicates that in normal life vascular damage is a rather common event and that hence the role of platelets in maintaining a normal hemostasis is a continuously ongoing physiological process. Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix resulting in platelet activation and aggregation to form a hemostatic plug. This self-amplifying mechanism nevertheless requires a tight control to prevent uncontrolled platelet aggregate formation that eventually would occlude the vessel. Therefore endothelial cells produce inhibitory compounds such as prostacyclin and nitric oxide that limit the growth of the platelet thrombus to the damaged area. With this review, we intend to give an integrated survey of the platelet response to vascular injury in normal hemostasis.
相关主题: Hematology, Oncology and Palliative Medicine, Signal transduction, Platelet adhesion, Activation, Secretion and aggregation, GAMMA-CHAIN COMPLEX, COLLAGEN-INDUCED AGGREGATION, NITRIC-OXIDE SYNTHASE, VON-WILLEBRAND-FACTOR, FACTOR SELF-ASSOCIATION, RECEPTOR INTEGRIN ALPHABETA, DIFFERENTIAL PROTEOME ANALYSIS, GLYCOPROTEIN-IB-ALPHA, P2X ION-CHANNEL, HEMATOLOGY, MYOSIN LIGHT-CHAIN, Animals, Hemostasis - physiology, Signal Transduction, Endothelium, Vascular - metabolism, Humans, Platelet Activation - physiology, Platelet Adhesiveness - physiology, Platelet Aggregation - physiology, Blood Platelets - physiology, Nitrogen oxide, Fibrin, Inositol, Myosin, Fibrinogen, Von Willebrand factor, Physiological aspects, CEA (Oncology),

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