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期刊名称: Trends in Biotechnology
Volume:15    Issue:8        Page:302-307
ISSN:0167-7799

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency期刊论文

作者: Shultz Leonard D Rajan Thiruchandurai V Greiner Dale L
DOI:10.1016/S0167-7799(97)01060-3

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页码: 302-307
被引频次: 122
出版者: Elsevier Ltd,ELSEVIER SCI LTD
期刊名称: Trends in Biotechnology
ISSN: 0167-7799
卷期: Volume:15    Issue:8
语言: English
摘要: Spontaneous mouse mutations that cause severe immunodeficiency or autoimmunity are invaluable tools with which to investigate the mammalian immune system. Mutations at the ‘motheaten’ locus result in severe immunological dysfunction due to disruption of the structural gene encoding Src-homology 2-domain phosphatase-1 (SHP-1). This natural model for a specific protein-tyrosine-phosphatase deficiency is being widely utilized to determine the role of SHP-1 in the negative regulation of multiple signaling pathways in a number of hematopoietic lineages.
相关主题: B-LYMPHOCYTES, ACTIVATION, LYMPHOPOIESIS, VIABLE MOTHEATEN MICE, K DB BIOTECHNOLOGY & APPLIED MICROBIOLOGY, BIOTECHNOLOGY & APPLIED MICROBIOLOGY, BONE-MARROW CELLS, MOTH-EATEN, ME ME, ASSOCIATION, LOCUS, EATEN MUTANT MICE, Immunologic Deficiency Syndromes - enzymology, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Intracellular Signaling Peptides and Proteins, Protein Tyrosine Phosphatases - metabolism, Mutation - immunology, Protein Tyrosine Phosphatases - immunology, Hematopoiesis - immunology, Animals, Protein Tyrosine Phosphatases - deficiency, Immunologic Deficiency Syndromes - genetics, Gene Expression Regulation, Enzymologic - immunology, Immunologic Deficiency Syndromes - immunology, Protein Phosphatase 1, Protein Tyrosine Phosphatase, Non-Receptor Type 6,

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