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作者 : Vladimir L. Gabai ;   Victor I. Shifrin ;  
ISSN : 0883-0185;1563-5244;
出版时间 : 2014
卷期 : 33(5)
起始页码 : 375
终止页码 : 382
摘要 : Cancer immunotherapy is a thriving field, but its clinical achievements are modest so far. One of its major hurdles seems to be finding a feasible cancer antigen as a target for immune response. After many years of research, three major criteria for choice of tumor antigens emerged. An antigen should be: (i) immunogenic; (ii) essential for cancers cells (to avoid its loss through immunoediting), but dispensable for normal tissues to reduce the risk of toxicity, and (iii) overexpressed in tumors as compared to the normal tissues. Here we argue that p62 (SQSTM1), a protein involved in autophagy and signal transduction, fits all the above criteria and can be chosen as a novel cancer antigen. Accordingly, we carried out an extensive study and found antitumor and antimetastatic activity of p62-encoding DNA vaccine in five types of commonly used transplantable tumor models of mice and rats, and spontaneous tumors in several dogs. Given that toxicity of p62 vaccine was minimal, if any, we believe that p62-encoding vaccine merits further clinical development.


Feasibility Analysis of p62 (SQSTM1)—Encoding DNA Vaccine as a Novel Cancer Immunotherapy期刊论文

作者:Vladimir L. Gabai,Victor I. Shifrin等 ISSN:0883-0185;1563-5244;  publication-date:2014-10  Volume:33  Issue:5  Page:375-382  

TLR Cross-talk Confers Specificity to Innate Immunity期刊论文

作者:Rebecca S. T. Tan,Bow Ho,Bernard P. Leung,Jeak L. Ding等 ISSN:0883-0185;1563-5244;  publication-date:2014-11  Volume:33  Issue:6  Page:443-453  

Alternative Medicines as Emerging Therapies for Inflammatory Bowel Diseases期刊论文

作者:Udai P. Singh,Narendra P. Singh,Brandon Busbee,H. Guan,Balwan Singh,Robert L. Price,Dennis D. Taub,Manoj K. Mishra,Mitzi Nagarkatti,Prakash S. Nagarkatti等 ISSN:0883-0185;1563-5244;  publication-date:2014-7-12  Volume:31  Issue:1  Page:66-84  

Perspective for Prophylaxis and Treatment of Cervical Cancer: An Immunological Approach期刊论文

作者:Marjorie Jenkins,Maurizio Chiriva-Internati,Leonardo Mirandola,Catherine Tonroy,Sean S. Tedjarati,Nicole Davis,Nicholas D’Cunha,Lukman Tijani,Fred Hardwick,Diane Nguyen,W. Martin Kast,Everardo Cobos等 ISSN:0883-0185;1563-5244;  publication-date:2014-9-10  Volume:31  Issue:1  Page:3-21  

Immunological Treatment Options for Locoregionally Advanced Head and Neck Squamous Cell Carcinoma期刊论文

作者:Christopher Schutt,Klaus Bumm,Leonardo Mirandola,Giovanni Bernardini,Nicholas D’ Cunha,Lukman Tijani,Diane Nguyen,Joehassin Cordero,Marjorie R. Jenkins,Everardo Cobos,W. Martin Kast,Maurizio Chiriva-Internati等 ISSN:0883-0185;1563-5244;  publication-date:2014-9-10  Volume:31  Issue:1  Page:22-42  

The Emerging Role of Leptin Antagonist as Potential Therapeutic Option for Inflammatory Bowel Disease期刊论文

作者:Udai P. Singh,Narendra P. Singh,Hongbing Guan,Brandon Busbee,Robert L. Price,Dennis D. Taub,Manoj K. Mishra,Raja Fayad,Mitzi Nagarkatti,Prakash S. Nagarkatti等 ISSN:0883-0185;1563-5244;  publication-date:2014-8-28  Volume:33  Issue:1  Page:23-33  

Role of Pathogens in Multiple Sclerosis期刊论文

作者:Jane E. Libbey,Matthew F. Cusick,Robert S. Fujinami等 ISSN:0883-0185;1563-5244;  publication-date:2015-3-17  Volume:33  Issue:4  Page:266-283  

Neutropenia during HIV Infection: Adverse Consequences and Remedies期刊论文

作者:Xin Shi,Matthew D Sims,Michel M Hanna,Ming Xie,Peter G Gulick,Yong-Hui Zheng,Marc D Basson,Ping Zhang等 ISSN:0883-0185;1563-5244;  publication-date:2016-5-11  Volume:33  Issue:6  Page:511-536  

Role of Endocannabinoid Activation of Peripheral CB1 Receptors in the Regulation of Autoimmune Disease期刊论文

作者:Jessica Margaret Sido,Prakash S. Nagarkatti,Mitzi Nagarkatti等 ISSN:0883-0185;1563-5244;  publication-date:2014-7-11  Volume:34  Issue:5  Page:403-414  

Rheumatic Fever, Autoimmunity and Molecular Mimicry: The Streptococcal Connection期刊论文

作者:Madeleine W. Cunningham等 ISSN:0883-0185;1563-5244;  publication-date:2015-11-25  Volume:33  Issue:4  Page:314-329  





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